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Thermo Scientific Chemicals Moxifloxacin hydrochloride
Moxifloxacin hydrochloride, CAS # 186826-86-8, is a broad-spectrum compound with antibacterial activity against both gram-positive and gram-negative bacteria. It also shows inhibitory activity against topoisomerase II.
Brand: Thermo Scientific Chemicals 457960010
241.90 EUR valid until 2025-12-31
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| Quantity | 1 g |
|---|
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Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Moxifloxacin hydrochloride is a fourth-generation synthetic fluoroquinolone compound with antibacterial activity against both gram-positive and gram-negative bacteria
• It also shows an inhibitory activity against topoisomerase II
• Moxifloxacin hydrochloride can bind to and inhibit both bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in DNA replication and repair inhibition thus induce cell death in sensitive bacterial species
• Moxifloxacin has 100 times higher affinity for bacterial DNA gyrase compared to mammalian DNA gyrase
Applications
• Moxifloxacin hydrochloride presents a higher anti-gram-positive activity compared to other fluoroquinolone such as ciprofloxacin and ofloxacin
• It has immunosuppressive activity that inhibits the proliferation of all classes of lymphocytes, which can induce apoptosis of antigen-presenting T cells
• It is a cytostatic anthracenedione that can intercalate DNA, increasing the occurence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA
• This compound shows anticancer activity in some animal models presenting leukemia
• Moxifloxacin is being investigated for the treatment of multidrug-resistant tuberculosis strains
Specifications
| Moxifloxacin Hydrochloride | |
| 324.0°C to 325.0°C | |
| 5% max. | |
| C21H25ClFN3O4 | |
| COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl | |
| 437.896 | |
| CHEBI:7008 | |
| ≥97.5% (HPLC) |
| 186826-86-8 | |
| Authentic | |
| 1 g | |
| IDIIJJHBXUESQI-DFIJPDEKSA-N | |
| 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydrochloride | |
| 101526 | |
| 437.89 | |
| Moxifloxacin hydrochloride |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Moxifloxacin hydrochloride
Signal Word
- Warning
Hazard Category
- Acute toxicity Category 4
- LONG-TERM AQUATIC HAZARD Chronic 3
- Serious eye damage/eye irritation Category 2
Hazard Statement
- H302-Harmful if swallowed.
- H319-Causes serious eye irritation.
- H412-Harmful to aquatic life with long lasting effects.
Precautionary Statement
- P264-Wash face, hands and anyexposed skin thoroughly after handling.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
Supplemental information
- MIXTURE LIST-Contains : Moxifloxacin hydrochloride
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Product Title
Thermo Scientific Chemicals Moxifloxacin hydrochloride > 1g; Glass bottle
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