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Cryopreserved Rat Kupffer Cells

Brand: Gibco RTKCCS

Product Code. 11380822

524.00 EUR / Each

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Description

These cryopreserved purified Kupffer cells are isolated from adult male Sprague-Dawley rats. Each vial contains a minimum of one million cells.

Easy to use cryopreserved Kupffer cells provide a convenient way to produce custom cell ratios for hepatic co-culture.

Each lot of Cryopreserved Rat Kupffer Cells is tested for:

Purity
Response to activation with LPS
Adherence

Minimum 1 million cells per vial

Kupffer Cells for Improved Physiological Modeling
Growing evidence shows that under both normal and pathological conditions, many hepatocyte functions are regulated by substances released from neighboring non-parenchymal cells (NPC). These cells, particularly Kupffer cells, play an important role in the modulation of xenobiotic metabolism in the liver. Kupffer cells secrete potent mediators of the inflammatory response that controls liver inflammation. These cytokine mediators control hepatocyte metabolic rates through direct interactions with phase I and phase II enzymes. Kupffer cell and hepatocyte co-cultures can self-assemble within 72 hours of treatment with pro-inflammatory cytokines or LPS, and can function by effectively modulating P450 expression, thus giving a more physiologically relevant result. Studies indicate that co-culture of hepatocytes with NPCs would better represent both normal liver physiology as well as disease states.

For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.,

Note:
These products require shipment in LN₂ vapor dewars therefore additional fees may apply.

Specifications

Cell Passage Number	Passage 0
Cell Type	Macrophage Cells
Form	Cryopreserved
Species	Rat
Donor Attributes	Normal
Format	Tube
Product Line	CellzDirect™
Quantity	1 vial

Content And Storage	1 vial of 1 million viable rat (Sprague-Dawley) Kupffer cells. Store in a cryostorage dewar or −135°C freezer.
Culture Type	Adherent Cell Culture
Gender	Male
Tissue	Liver
Donor Source	Pooled
No. of Cells	1 x 10⁶
Product Type	Rat Kupffer Cell
Tested For	Purity, Response to Activation with LPS, Adherence, Minimum 1 Million Cell per Vial

Product Suggestions Documents

Documents

Product Information

Manuals

Product Sheet: Cryopreserved Human and Rat Kupffer Cells Version: 2.0 File size: 147.2 kB

Certificates

A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.

Lot Number

5 results found

Lot Number	Certificate Type	Date	Catalog Number
Lot NumberRCC147	Certificate TypeCertificate of Analysis	Date29/01/2025	Catalog NumberRTKCCS
Lot NumberRCC146	Certificate TypeCertificate of Analysis	Date29/01/2025	Catalog NumberRTKCCS
Lot NumberRCC150	Certificate TypeCertificate of Analysis	Date26/01/2025	Catalog NumberRTKCCS
Lot NumberRCC151	Certificate TypeCertificate of Analysis	Date26/01/2025	Catalog NumberRTKCCS
Lot NumberRCC152	Certificate TypeCertificate of Analysis	Date25/01/2025	Catalog NumberRTKCCS

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