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Bleomycin sulfate

Bleomycin sulfate, CAS # 9041-93-4, is a glycopeptide compound with antibiotic activity isolated from Streptomyces verticillus. It also exhibits anticancer activity. | CAS: 9041-93-4 | C55H85N17O25S4 | 1512.619 g/mol

Brand:  Thermo Scientific Alfa Aesar J60727.MA

334.66 EUR valid until 2025-06-30
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Quantity 10 mg

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Product Code. 15483439

  • 380.00 EUR / 10mg
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Description

Description

Bleomycin sulfate is used as a glycopeptide antibiotic. It is capable of inducing oxidative cleavage of the DNA backbone, leading to apoptosis and also degrades RNA, and has been reported to display selectivity for RNA over DNA. Bleomycin acts as a sclerosing agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
  • It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
  • Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation

Application

  • It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
  • Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
  • Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
  • In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice
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Lot Number Certificate Type Date Catalog Number
Lot NumberR23L011 Certificate TypeCertificate of Analysis Date25/05/2025 Catalog NumberJ60727.M^,J60727.MC,J60727.MA
Lot NumberQ01L004 Certificate TypeCertificate of Analysis Date17/05/2025 Catalog NumberJ60727.M^,J60727.MC,J60727.MA
Lot NumberQ17L002 Certificate TypeCertificate of Analysis Date17/05/2025 Catalog NumberJ60727.M^,J60727.MC,J60727.MA
Lot NumberN11L022 Certificate TypeCertificate of Analysis Date13/02/2025 Catalog NumberJ60727.MA
Lot NumberM31L021 Certificate TypeCertificate of Analysis Date03/02/2025 Catalog NumberJ60727.MA
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