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ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor™ 488, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA339100A488
This item is not returnable.
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Description
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Specifications
| ZO-1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4 | |
| O97758, Q07157 | |
| TJP1 | |
| Human recombinant ZO-1 fusion protein encompassing amino acids 334-634 | |
| 50 μL | |
| Primary | |
| Canine, Human | |
| Antibody | |
| IgG1 |
| Immunocytochemistry | |
| ZO1-1A12 | |
| Alexa Fluor 488 | |
| TJP1 | |
| DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1 | |
| Mouse | |
| Affinity chromatography | |
| RUO | |
| 403752, 7082 | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Liquid |