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PHLPP Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 22789-1-AP-150UL

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Product Code. 16812095

  • 399.00 EUR / 150µL

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Description

Description

PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Specifications

Specifications

PHLPP
Polyclonal
Unconjugated
PHLPP1
hSCOP, KIAA0606, PHLPP, PHLPP1, PLEKHE1, SCOP
Rabbit
Antigen Affinity Chromatography
RUO
23239, 98432
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.57 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O60346, Q8CHE4
Phlpp1
PHLPP Fusion Protein Ag18794
150 μL
Primary
Human, Mouse
Antibody
IgG
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