CD30 (Reed-Sternberg Cell Marker) Ab-4 Mouse Monoclonal Antibody, Epredia™

Description

CD30, a single chain glycoprotein, is synthesized as a 90 kDa precursor which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120kDa glycoprotein. The CD30/Ki-1 antigen is expressed by mononuclear Hodgkin and multinucleated Reed-Sternberg cells in Hodgkin's disease, by the tumor cells of a majority of anaplastic large cell lymphomas, and by a varying proportion of activated T and B cells. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).

Host Species: Mouse

Clone: HRS4

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: Extracellular domain

Immunogen: Recombinant extracellular domain of CD30 protein

Molecular Weight: 120 kDa (mature), 95 kDa (precursor)

Positive Control: Hodgkin's lymphoma

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)